Publication - Abstract
Feb 16, 2021
Communications Biology
M.J. Munson, G. O'Driscoll, A.M. Silva, E. Lázaro-Ibáñez, A. Gallud, J.T. Wilson, A. Collén, E.K. Esbjörner and A. Sabirsh
RNA-based therapies have great potential to treat many undruggable human diseases. However, their efficacy, in particular for mRNA, remains hampered by poor cellular delivery and limited endosomal escape. Development and optimisation of delivery vectors, such as lipid nanoparticl...
Read More
Publication - Abstract
Apr 08, 2020
Molecular Pharmaceutics
K. Zhou, L.T. Johnson, H. Xiong, S. Barrios, J.T. Minnig, Y. Yan, B. Abram, X. Yu and D.J.Siegwart
In this work, a series of linear-dendritic poly(ethylene glycol) (PEG) lipids (PEG-GnCm) were synthesized through a strategy using sequential aza- and sulfa-Michael addition reactions. The effect of modulating the hydrophobic domain of linear-dendritic PEG lipids was systematical...
Read More