Advances in Development of mRNA-Based Therapeutics


Authors: L. Huang, L. Zhang, W. Li, S. Li, J. Wen, H. Li and Z. Liu

Journal: Current Topics in Microbiology and Immunology

DOI: https://doi.org/10.1007/82_2020_222

Publication - Abstract

July 19, 2020

Other Applications Nucleic Acid Lipid Nanoparticles Polymeric Nanoparticles
Recently, mRNA-based therapeutics have been greatly boosted since the development of novel technologies of both mRNA synthesis and delivery system. Promising results were showed in both preclinical and clinical studies in the field of cancer vaccine, tumor immunotherapy, infectious disease prevention and protein replacement therapy. Recent advancements in clinical trials also encouraged scientists to attempt new applications of mRNA therapy such as gene editing and cell programming. These studies bring mRNA therapeutics closer to real-world application. Herein, we provide an overview of recent advances in mRNA-based therapeutics.

limit search to this category
Advanced Search

Advanced Search

close
  • Publications
  • Application Notes
  • Posters
  • Workshops
  • Videos & Webinars
  • Articles
Search

Browse by Category

  • Application
    • Diagnostic and Imaging
    • Genetic Medicine
    • Hematology
    • Metabolic Disorders
    • Neuroscience
    • Oncology
    • Skeletal Disorders
    • Targeted Drug Delivery
    • Vaccines
    • Other Applications
    • Cell therapy
  • Formulation
    • Liposomes
    • Nucleic Acid Lipid Nanoparticles
    • Polymeric Nanoparticles
    • Other Formulations
  • Payload
    • DNA
    • microRNA
    • mRNA
    • siRNA
    • Small Molecule Drugs
    • Other Payloads


related content

Publication - Abstract

Dec 10, 2020
Journal of Orthopaedic Research

Diflunisal‐loaded Poly(propylene sulfide) Nanoparticles Decrease S. aureus‐mediated Bone Destruction During Osteomyelitis

C.A. Ford, T.J. Spoonmore, M.K. Gupta, C.L. Duvall, S.A. Guelcher and J.E. Cassat

Small Molecule Drugs Skeletal Disorders Polymeric Nanoparticles
Read More


Publication - Abstract

Dec 05, 2018
Journal of Drug Delivery Science and Technology

Microfluidic Manufacturing Improves Polydispersity of Multicomponent Polymeric Nanoparticles

K. Abstiens and A.M. Goepferich

Polymeric Nanoparticles
A key challenge in manufacturing of multicomponent polymeric colloids is obtaining monodisperse nanoparticles (NPs) with reproducible characteristics. Herein, NP formulations with varying core to shell ratios were either prepared by bulk nanoprecipitation or microfluidic synthesi...
Read More


Sign Up and Stay Informed
Sign up today to automatically receive new Cytiva, formerly Precision NanoSystems application notes, conference posters, relevant science publications, and webinar invites.
Sign Up