Publication - Abstract
May 13, 2021
Nature Communications
C. Hunt, S.A. Hartford, G. Gong, et al
The paper demonstrates PNI's mRNA-LNP as highly capable of inducing strong levels of upregulation in target genes with activation levels six to nine fold dependent on amount of gRNA packaged. The paper validates the SAM system in mice as a suitable in vivo model encompassing both...
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Publication - Abstract
Jun 22, 2020
Small
E. Cörek, G. Rodgers, S. Siegrist, T. Einfalt, P. Detampel, C.M. Schlepütz, S. Sieber, P. Fluder, G. Schulz, H. Unterweger, C. Alexiou, B. Müller, M. Puchkov and J. Huwyler
Metal‐based nanoparticles are clinically used for diagnostic and therapeutic applications. After parenteral administration, they will distribute throughout different organs. Quantification of their distribution within tissues in the 3D space, however, remains a challenge owing to...
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