Microfluidic-Based Manufacture of siRNA-Lipid Nanoparticles for Therapeutic Applications

Publication - Abstract

Sep 09, 2021
Signal Transduction and Targeted Therapy

The Self-Assembled Nanoparticle-Based Trimeric RBD mRNA Vaccine Elicits Robust and Durable Protective Immunity Against SARS-CoV-2 in Mice

W. Sun, L. He, H. Zhang, X. Tian, Z. Bai, L. Sun, L. Yang, X. Jia, Y. Bi, T. Luo, G. Cheng, W. Fan, W. Liu & J. Li

In a publication written by scientists, Sun et al. 2021, from the CAS Key Laboratory of Pathogenic Microbiology and Immunology at the Chinese Academy of Sciences, endeavored to develop a broad-spectrum multivalent vaccine to combat rapidly emerging variants of SARS-CoV-2. Their a...

Publication - Summary

Nov 21, 2018
Blood

Effective Lipidoid Nanoparticle Delivery In Vivo of siRNA Targeting Kappa Light Chain Production in a Murine Xenograft Model

X. Ma, P. Zhou, A. Kugelmass, D. Toskic, M. Warner, L.X. Lee, T. Fogaren, M. Wang, Y. Li, L. Yang, Q. Xu and R. Comenzo

siRNA Oncology Hematology

Researchers at Tufts University have recently reported a proof of concept for siRNA-LNP treatment for AL amyloidosis - a bone marrow disorder where Immunoglobulin (Ig) light chains (LC) misfold into amyloids that deposit in a variety of other tissues where they cause disfunction ...