Publication - Abstract
Feb 11, 2021
Nano Letters
D.E. Murphy, O.G. de Jong, M.J.W. Evers, M. Nurazizah, Y.M. Schiffelers and P. Vader
RNA therapeutics have high potential that is yet to be fully realized, largely due to challenges involved in the appropriate delivery to target cells. Extracellular vesicles (EVs) are lipid bound nanoparticles released by cells of all types and possess numerous features that may ...
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Publication - Abstract
Apr 13, 2021
Pharmaceutics
H. Tanaka, N. Takata, Y. Sakurai, H. Akita et. al.
The world-first success of lipid nanoparticle (LNP)-based siRNA therapeutics (ONPATTRO®) promises to accelerate developments in siRNA therapeutics/gene therapy using LNP-type drug delivery systems (DDS). In this study, we explore the optimal composition of an LNP containing a...
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