What is
Nanomedicine?

Revolutionizing Medicine

Following biologics, nanomedicines represent the next era in drug innovation. Current research has demonstrated improved performance, reduced side effects, and revolutionary new treatment strategies like personalized medicine.

Several nanomedicines are available on the market such as Doxil, Visudyne, and Vyxeos. The most clinically advanced RNA medicine—Patisiran—is enabled by lipid nanoparticle (LNP) technology.

Commonly, nanomedicines consist of active pharmaceutical ingredients (API) such as small molecules or biologics packaged into nano-sized carriers made of excipients like lipids and polymers. Nanoparticles tend to be smaller than cells but larger than most biomolecules, so the nanomedicine can interact with the body differently than the API alone. The properties of nanomedicines can be designed to control when and where in the body the API is available.

Applications of Nanomedicine

By packaging a variety of active pharmaceutical ingredients (API) into nanoparticles, drug innovators aim to:

Protect the API

Control API Release

Alter Biodistribution

Target drug delivery
to the site of disease

Enhance solubility
and bioavailability

Nanomedicines are at the Heart of Next-Generation Medicines

Nanomedicines currently being developed, allow treatment of otherwise "undruggable" targets to address unmet medical needs through revolutionary new strategies:

Nanomedicine: Future of Medicine

The Challenge

Using traditional methodologies, drug researchers face significant challenges in producing nanomedicines for R&D, clinical testing, and commercial manufacture.

Lipid Nanoparticle v Small Molecule

Nanoparticles consist of millions of molecules that need to come together and work in concert, and traditional production methods adapted from processes developed over decades for small molecule drugs do not adequately address the unique needs of nanomedicine production.

Learn More About Lipid Nanoparticles

Traditional Methods:

Lack Consistency
Are laborious/slow/low throughput	Doxil process: 10 Steps 17 Process vessels 5 Days
Are difficult to scale
Require expertise/skill

Advanced Solutions for Advanced Medicines

Precision NanoSystems is enabling drug innovators to overcome unique challenges in creating transformative medicine by making purpose-designed manufacturing technology and unique nanomedicine expertise available to support all stages of nanomedicine development.

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Resource Center

Poster

September 01, 2022

Scale Up Genome Editing of CAR T Cells using Lipid Nanoparticles

Genome Editing of Human Primary T Cells with Lipid Nanoparticles

Delivery of Self-amplifying mRNA Vaccines by Cationic Lipid Nanoparticles: The Impact of Cationic Lipid Select...

G. Lou, G. Anderluzzi, S.T. Schmidt, S. Woods, S. Gallorini, M. Brazzoli, F. Giusti, I. F...

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Publication - Abstract

May 08, 2020

Vaccines

Investigating the Impact of Delivery System Design on the Efficacy of Self-Amplifying RNA Vaccines

G. Anderluzzi, G. Lou, S. Gallorini, M. Brazzoli, R. Johnson, D.T. O'Hagan, B.C. Baudner a...

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Publication - Abstract

April 02, 2020

Journal of Controlled Release

Design of a Novel Vaccine Nanotechnology-based Delivery System Comprising CpGODN-protein Conjugate Anchored to...

D. Chatzikleanthous, S.T. Schmidt, G. Buffi, I. Paciello, R. Cunliffe, F. Carboni, M.R. Ro...

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Publication - Abstract

December 31, 2019

Vaccines

Investigating Prime-Pull Vaccination through a Combination of Parenteral Vaccination and Intranasal Boosting

C.B. Roces, M.T. Hussain, S.T. Schmidt, D. Christensen and Y. Perrie

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Resource Center 资源中心

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