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To learn how Precision NanoSystems accelerates nanomedicine development from an idea to clinical applications, contact our Technical Sales Team.
Get in TouchCOVID-19 Vaccines & Genetic Medicines
PNI has had one clear mission; To accelerate the creation of transformative medicine that significantly impacts human well-being. Today our mission is more important than ever as we work together to combat COVID-19. PNI offers an integrated suite of proprietary technology, nanomedicine expertise and custom services to empower you to accelerate your work at the pace the world demands.
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Validated NanoAssemblr GMP System for centralized or in-country manufacturing of nanoparticle-based therapeutics at different scales
Modular and configurable design with experience in integrating with other technology components to build an end-to-end manufacturing solution
Clinical Solutions team with expertise to support formulation development, scale-up and tech transfer for rapid and successful GMP manufacturing
Synthetic vaccine without the complications of a packaging cell line, contamination with replication competent virus and anti-vector immunity formulations offer a desirable alternative to viral delivery and with NanoAssemblr® technology,
these formulations can be prepared on demand in seconds.
Projections are to be able to produce 5 million human doses per liter via enzymatic synthesis
Requires an LNP delivery system specifically design for gene vaccine applications
Requires a scalable nanoparticle manufacturing platform
Once established, concept can be applied to future pandemics, raw material are generic and can be stockpiled
Challenges with Conventional Methods | Benefits of NanoAssemblr® Technology | |
Limited control over particle size | Fine-tune particle size by changing formulation parameters | |
Significant batch-to-batch variability | Laminar conditions lead to highly reproducible mRNA lipid nanoparticles | |
Substantial material loss from low encapsulation efficiency | Achieve high mRNA encapsulation efficacy and potency | |
A labor-intensive production process that is difficult to scale-up | Rapidly produce formulations for screening and optimization with a straightforward path to scale-up for clinical applications |
Application Note
March 15, 2022
Publication - Abstract
July 01, 2020
Journal of Controlled Release
Publication - Abstract
May 08, 2020
Vaccines
Publication - Abstract
May 31, 2019
Vaccine
Publication - Summary
May 17, 2019
Science Immunology
To learn how Precision NanoSystems accelerates nanomedicine development from an idea to clinical applications, contact our Technical Sales Team.
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