Publication - Summary
Feb 07, 2019
Molecular Therapy Nucleic Acids
K.J Hassett, K.E. Benenato, E. Jacquinet, L.A. Brito, et al.
mRNA vaccines have the potential to tackle many unmet medical needs that are unable to be addressed with conventional vaccine technologies. A potent and well-tolerated delivery technology is integral to fully realizing the potential of mRNA vaccines. Pre-clinical and clinical stu...
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Publication - Abstract
Nov 21, 2016
Nanoscale
W. Viricel, S. Poirier, A. Mbarek, R.M. Derbali, G. Mayer and J. Leblond
A pH-sensitive molecular switch able to change its conformation upon protonation at endosomal pH values is embedded into the structure of cationic lipidoid materials, thus conferring endosomal escape properties. Involvement of the conformational switch in the endosomal escape pro...
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