Publication - Abstract
Jun 01, 2020
MethodsX
D. Chatzikleanthous, R. Cunliffe, F. Carboni, M.R. Romano, D.T. O'Hagan, C.W. Roberts, Y. Perrie and R. Adamo
The well-known Toll like receptor 9 (TLR9) agonist CpG ODN has shown promising results as vaccine adjuvant in preclinical and clinical studies, however its in vivo stability and potential systemic toxicity remain a concern. In an effort to overcome these issues...
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Publication - Abstract
Jan 28, 2021
Hepatology
L. Allweiss, K. Giersch, A. Pirosu, T. Volz, R.C. Muench, R.K. Beran, S. Urban, H. Javanbakht, S.P. Fletcher, M. Lütgehetmann and M. Dandri
These results reveal that therapeutics abrogating all HBV transcripts including HBx promote epigenetic suppression of the HBV minichromosome, whereas strategies protecting the human hepatocytes from reinfection are needed to maintain cccDNA silencing.
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